Abstract

DESIGN AND CHARACTERIZATION OF ORODISPERSIBLE TABLETS OF CALCIUM CHANNEL BLOCKERS

Nitin Chaudhary*, Kapil Purohit and Sobhit Singh Rajput

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Abstract

Objective: Using sodium starch glycolate, croscarmellose sodium, kyron T-314, and crospovidone as super disintegrants to increase the disintegration and dissolution rates and assess the tablet's pre- and post-compression parameters was the goal of this study in order to create a fast-dissolving nimodipine tablet. Methods: Nimodipine fastdissolving tablets were made using the direct compression method. The fast dissolving tablet was assessed for weight variation, thickness, hardness, friability, wetting time, water absorption ratio, disintegration time, and dissolution time. Pre-compression parameters included bulk density, tapped density, Hausner's ratio, angle of repose, and Carr's index. The fast-dissolving tablet formulation of nimodipine's drug release has been quantified using the UV-spectrophotometric approach. Results: Pre and post compression parameter were evaluated. Bulk density (0.50-0.56 g/cm3) and Tapped density (0.60-0.65g/cm3). The hardness, friability, wetting time, the water absorption ratio, disintegration and dissolution time were found to be acceptable according to the standard limit and compare to all formulations. All batches of fast dissolving tablet were satisfactory in term of dissolution. The drug release from tablets of nimodipine tablets found to be in the range of 99.36 to 99.90%, DCP4 is best of all formulations with disintegration time 11.18 sec, hardness (3.3 Kg/cm²) and percentage friability (0.62 %). Conclusion: The outcome revealed that, in accordance with standard limits, the dissolution and disintegration of Nimodipine Tablets was deemed acceptable. Super disintegrants can be added to the direct compression approach to significantly increase the rate of disintegration and dissolution of nimodipine.

Keywords: Fast dissolving tablet, Nimodipine, Sodium starch glycolate, Crospovidone.