Abstract

REVIEW ON: SUBLINGUAL DRUG DELIVERY SYSTEM

Rutuja Virchand Yarmal* and Dr. Ganesh D. Basarkar

.

Abstract

Sublingual administration is frequently utilized for medications that are metabolized or degraded in the gastrointestinal tract first. Drug administration through the oral mucous membrane is seen to be a promising alternative to the oral route. Sublingual administration offers faster onset of action and more patient compliance compared to oral tablets or pills. Fast disintegrating sublingual tablets release drugs beneath the tongue and breakdown quickly within minutes. The sublingual portion of the oral cavity (the floor of the mouth) has higher permeability than the buccal (cheek) and palatal (roof of the mouth) areas. Sublingual blood vessels absorb the medication, bypassing hepatic first-pass metabolism, resulting in satisfactory bioavailability. Various techniques are utilized to create sublingual dosage forms. New sublingual technologies address a wide range of pharmaceutical and patient demands, from improved life-cycle management and simple dosage for dysphagic pediatric, geriatric, and psychiatric patients. This study covers the benefits, drawbacks, sublingual gland, and factor affecting the sublingual absorption.

Keywords: Sublingual delivery, Oral cavity, Improved bioavailability, Dysphagia.