Abstract

A REVIEW ARTICLE ON ANALYTICAL METHODS FOR COMBINATION OF DRUGS: BENIDIPINE HYDROCHLORIDE AND TELMISARTAN

Rana Yukti*, Tanmay Shah, Nandini Modi, Rumana Dutiya, Dr. Nidhi Chauhan and Dr. Drashti Mandale

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Abstract

High blood pressure, also called hypertension, is a common condition that is characterized by having a higher amount of pressure in blood vessels than normal. Hypertension (HT) is a very common disorder, particularly past middle age. It is not a disease in itself, but is an important risk factor for cardiovascular mortality and morbidity. For improvement activity of hypertension, Benidipine HCl and Telmisartan newer combination in market, which is effective in Hypertension. This combination was developed to improve medication for Stage II Hypertension. Benidipine HCl is dihydropyridine calcium channel blocker and chemically 3-(3R)-1-benzylpiperidin-3-yl 5- methyl (4R)- 2, 6-dimethyl-4-(3-nitrophenyl)-1, 4-dihydropyridine-3, 5- dicarboxylate hydrochloride. Telmisartan is AT1-receptor blocker and Chemically2-{4-[[4-methyl-6-(1-methylbenzimidazol-2yl)-2– propylbenzimidazol-1yl] methyl] biphenyl)- benzoic acid. It provides information about different analytical method development like UV spectrophotometry, HPTLC, HPLC, Stability studies Forced Degradation Study, spectroflourimetry methods reported for Benidipine HCl and Telmisartan for individual and other drug combination. All reported methods found to be simple, accurate, economic, precise and reproducible in nature. This Review focuses on development in analytical method development for Benidipine HCl and Telmisartan, and there were two methods reported for this combination as per our knowledge.

Keywords: Benedipine HCl, Telmisartan, Analytical method, Hypertension, Combination of Drug.