Abstract

A REVIEW ON NASAL DRUG DELIVERY SYSTEM

Utkarsha Bajirao Dhurgude* and Vasundhara Bhosale

Abstract

The purpose of this review is to reconsider mechanisms. Using PubMed, Google Scholar, Google, and Research Gate, a literature survey was conducted. The nasal lining has a sizable region of endothelium with a high blood supply and variable permeability. This pathway has the advantage of not requiring first-pass metabolism and being readily accessible. Certain substances, such as low molecular mass chemicals with high polarity, peptides, or proteins, that would be difficult to deliver otherwise can enter the systemic circulation through the nasal route. The three main elements that determine how much a medicine may be absorbed via the nasal lining are the drug's physicochemical properties, the function of the mucociliary system in the nose, and the existence ofDrugs can be absorbed through nasal cavity.A primary constraint on the utilisation of the intranasal delivery method is inadequate absorption via the nasal mucosa. Many medications under development have low bioavailability after nasal administration, making them unsuitable for intranasal administration. Much study has been conducted on ways to improve absorption via the nasal route. In this article, we review the literature related to mechanism of nasal drug delivery and various devices used for delivery along with anatomy of human nasal cavity, advantage, disadvantages, limitations, factors affecting, additives and applications of the nasal drug delivery system.

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