Abstract

A COMPREHENSIVE REVIEW ABOUT THE DEVELOPMENT, CHARACTERIZATION AND SKIN DELIVERY STUDIES OF ULTRADEFORMABLE VESICLES: TRANSFERSOMES

Tushar Vashisth*, Ruchi Hooda, S. MD Sameer Qureshi, Bhaskar Pandey and Nithin A. Mathew

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Abstract

Transdermal delivery systems have attracted significant interest in recent years due to their advantages over traditional oral and parenteral delivery systems. These are self-administered, non-invasive delivery systems that improve patient compliance and enable controlled release of therapeutic agents. The biggest challenge with transdermal delivery systems is the barrier function of the outermost layer of the skin. Molecules with a molecular weight greater than 500 Da and ionized compounds generally do not pass through the skin. Therefore, the drugs that can be used in this way are limited. A possible solution to this problem is to encapsulate drugs in transfersomes. They feature a bilayer structure that facilitates the encapsulation of lipophilic and hydrophilic drugs as well as amphipathic drugs with higher permeation efficiency than traditional liposomes. The transfer thumb is elastic in nature and can deform and contract like an intact vesicle through a narrow opening significantly smaller than its size. This review aims to explain the concept of transfersomes, their mechanism of action, various methods of preparation and characterization, factors that influence the properties of transfersomes, and their current applications and role in drug delivery through the skin.

Keywords: Transfersomes, Nanoencapsulation, Transdermal drug delivery, Noninvasive.