Abstract

POLYMER MODIFICATION FOR COLON TARGETED DRUG DELIVERY SYSTEM: A COMPREHENSIVE REVIEW

*Deshmukh Ashish Nimba and Dr. Swaroop Lahoti

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Abstract

When treating colon disorders, colon-targeted dose forms are more focused and efficient. Because of their many advantages, polysaccharides have drawn a lot of attention from researchers in the field of medication delivery in recent years. These materials are thought to be the finest ones for creating targeted dosage forms. They are hydrophilic, stable, and non-toxic by nature. Enzymatic activity in colon breaks them down, but they remain intact as they transit through the upper gastrointestinal tract. This characteristic can be investigated to see if the medications can use or utilizing polysaccharides in the colon. Even if there are many polymers accessible and plays vital role in colon targeted drug delivery, there are situations when they cannot meet demand due to certain constraints; therefore, modifications must be made to them. Drug targeting may benefit from the gradual substitution of modified natural polymers for native polymers. The characteristics of polymers can be changed in the variety of methods, including blending, grafting, and curing. Polysaccharides are enhanced by grafting, which also makes them a perfect drug delivery carrier. This review discusses how grafting alters polysaccharides, a naturally occurring polymer, and functions as a potent drug carrier for colon targeted drug delivery as well as various method of polymer modification like polymer grafting, crosslinking, derivative formation, polymer- polymer blending etc.

Keywords: Polymer modification, grafted gum, colon targeting, drug release, natural polymers and polysaccharides.