Abstract

SCHIFF BASE AS A LEADING MOLECULE TO SYNTHESIZED HETEROCYCLIC COMPOUNDS AND ITS APPLICAION

Dr. D. D. Rishipathak, Sagar S. Deshmukh*, Shreyas P. Badgujar, Mayuri J. Deore, Rituja P. Ghatkar, Mayuri B. Jadhav, Saurabh S. Gaikwad, Purushottam N. Dhikale, Ashutosh R. Joshi

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Abstract

Schiff bases are substances with a carbon-nitrogen double bond in their structure that are created when aldehydes or ketones react nucleophilically with primary amines under certain circumstances. Because of their simple synthesis, these molecules—which are created by condensation of primary amines with carbonyl compounds like aldehydes or ketones—are regarded as preferred ligands. Ketones need more complicated circumstances to generate Schiff bases than aldehydes, which react with primary amines to form Schiff bases more easily. This entails selecting catalysts with care, preserving a suitable pH range, selecting a solvent that can combine with the water created during the reaction to form an azeotropic combination, and making sure the reaction temperature is right. In Schiff bases, the carbonnitrogen double bond that results from aldehyde reactions is referred to as Schiff bases.

Keywords: Schiffbases, Nucleophilic addition reaction, Aldehydes, Ketones, Privileged ligands, Imine, Ketimine.