Abstract

IN VITRO SCREENING OF EPI PREMNUM AUREUM FOR ANTI DIABETIC ACTIVITY

Om Uday Chiddarwar* and Divanshi Manik Motghare

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Abstract

Hyperglycemia is a chronic metabolic dysfunction that characterizes diabetes mellitus arising from disordered insulin secretions or actions or both. The aim of this study was to examine the anti-diabetic potential of E. Aureum, a popular ornamental plant. The stems and roots of E. Aureum were collected, verified and then extracted with petroleum ether and methanol solvents. Phytochemical screening and α-amylase inhibition assay in vitro were done on the extracts. Phytochemical analysis showed the presence of some bioactive compounds such as glycosides, terpenoids alkaloids phenolic compounds among other flavonoids too. The methanolic extract exhibited significant α-amylase inhibitory activity with its percentage inhibition ranging between 50.74-66.41 % at different concentrations (20-80 μg/mL). These findings indicate that E. Aureum extracts may possess antidiabetic potentials by inhibiting α-amylase which is responsible for carbohydrate digestion and glucose metabolism. This calls for more tests to be done in order to determine how these extract works against diabetes mellitus through antidiabetic activities as well as their therapeutic values in human beings suffering from diabetes mellitus.

Keywords: Epipremnum aureum, diabetes mellitus, antidiabetic activity, amylase inhibition, phytochemicals, in vitro screening.