Abstract

A REVIEW ON DENDRIMERS: SYNTHESIS, CHARACTERIZATION, PROPERTIES, TYPES, AND BIOMEDICAL APPLICATIONS

Snehal R. Patil*, Yash A. Gavali, B. A. Shingte and R. P. Devale

Abstract

This study offers a concise overview of dendrimers, including their production, characterization, and use in drug administration. Dendrimers have distinct molecular weights, sizes, shapes, and monodispersities. Due of these characteristics, dendrimers are a good carrier for applications involving drug delivery. The solubility of medications that are weakly soluble is increased by dendrimers, which are composed of several molecular entities of colloidal particles that exist in equilibrium with the molecules or ions in nature. Their unique structural design has given these better chemical and physical qualities. They are more adaptable since DNA, heparin, and polyanions are compatible. Molecules can self-assemble to create nanoscopic functional and structural systems more quickly. However, assessing their true efficacy in drug delivery requires acknowledging their in vivo behavior. Research has looked into the biological potential of dendrimers, including gene transfer, vaccine development, and the creation of antiviral, antibacterial, and anticancer treatments. Additionally, this article explains how the dendrimers have interactions with many medications, as well as the potential for these macromolecules to work with drug nanocarriers in the transdermal, ocular, respiratory, oral, and intravenous routes of delivery. For biomedicine, dendrimers guarantee improved potential protrusion. The physico-chemical characteristics of dendrimers and their possible applications in several fields of study, technology, and medicine are briefly covered in this overview.

Keywords: Dendrimer, Synthesis, Characterization, Properties, Application.