Abstract

HYDROALCHOLICGELS: A CRITICAL REVIEW OF FORMULATION, PROPERTIES, APPLICATION

Jasbir Kumar, Anmol Rana, *Amandeep Kaur, Evinka Barjataya and Dr. Naresh Singh Gill

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Abstract

Hydroalcoholic gels have gained widespread popularity as effective hand sanitizers due to their convenience, efficacy, and rapid action against a broad spectrum of pathogens. This study focuses on the development and evaluation of a novel hydroalcoholic gel formulation optimized for hand sanitization. The formulation comprises ethanol as the primary antimicrobial agent, along with a combination of moisturizing and thickening agents to enhance its efficacy and user experience. The development process involved systematic optimization of the formulation to achieve the desired antimicrobial efficacy, while also ensuring skin compatibility and pleasant sensory attributes. Various concentrations of ethanol, glycerin, and carbomer were tested to determine the optimal balance between antimicrobial activity, skin hydration, and gel viscosity. The final formulation demonstrated excellent antimicrobial efficacy against a variety of common pathogens, including bacteria, viruses, and fungi. Furthermore, the hydroalcoholic gel exhibited favorable characteristics such as quick drying, non-sticky residue, and a pleasant scent, making it suitable for frequent use in various settings including healthcare facilities, households, and public spaces. Stability studies confirmed the long-term stability of the formulation under different storage conditions, ensuring its effectiveness over time. In conclusion, the developed hydroalcoholic gel presents a promising solution for effective hand sanitization, offering both antimicrobial efficacy and user acceptability. Its formulation can be further optimized or customized to meet specific requirements or preferences, contributing to the ongoing efforts to promote hand hygiene and prevent the spread of infectious diseases.

Keywords: Hydroalcohlic gel, Hydrogels, drugs, Topical, Skin, Gel.