Abstract

DEVELOPING AND ASSESSING A TOPICAL DRUG DELIVERY SYSTEM INCORPORATING PHYTOCONSTITUENT FOR THE TREATMENT OF CONTACT DERMATITIS

Nidhika Kaundal* and Pravin Kumar

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Abstract

Objective: The objective of this study is to optimize a cream base and design a topical dosage form containing phytoconstituent for treating contact dermatitis, specifically focusing on its potential as an alternative for managing contact dermatitis. Method: A base cream was formulated by fusion method with varying concentration of cetyl alcohol, stearic acid, propylene glycol, triethanolamine and glycerine. Organoleptic and physicochemical properties were evaluated. The selected cream (CB1) was used for loading resveratrol and evaluated for physical characteristics, stability, drug content, ex-vivo diffusion study, skin retention, and microbial examination. Result: Controlled release was observed over 24 hours, with less than 1% release in buffer after 360 minutes. High drug retention in skin was noted for all formulations. Cream formulations remained stable after one month of storage. Conclusion: Resveratrol-loaded creams show promise as topical drug delivery system for treating contact dermatitis. Further in vivo studies are warranted to validate these findings.

Keywords: Contact Dermatitis (CD), Creams, Optimization, Resveratrol, Topical delivery.