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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

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Abstract

SYNTHESIS, SPECTRAL STUDIES AND ANTIMICROBIAL SCREENING OF SOME NEW CHALCONE AND QUINOLINE DERIVATIVES

Dhruva U. Dave*, Neha C. Bhoraniya, Heena C. Patel, Priyanka Pankhaniya and D. M. Purohit*

Abstract

(E)-3-(2’-amino-3’,5’-dibromophenyl)-1-(aryl) prop-2-en-1-ones (1a- 1l) and 2-aryl- 6,8-dibromoquinolines (2a-2l) were synthesized. The synthesized structures were validated through spectral analysis including IR, Mass, and 1H-NMR. The antimicrobial activity of compounds (1a-1l) and (2a-2l) was assessed against Gram positive bacteria (Bacillus subtilis, Staphylococcus aureus), Gram negative bacteria (Escherichia coli, Pseudomonas aeruginosa) and Fungi Aspergillus Niger.

Keywords: Heterocyclic compounds, quinolines, chalcones, antimicrobial activity, spectral studies.

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