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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

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Abstract

SYNTHESIS, SPECTRAL STUDIES AND ANTIMICROBIAL SCREENING OF SOME NEW CHALCONE AND ISOXAZOLE DERIVATIVES BEARING FURAN NUCLEUS

Dhruva U. Dave*, Heena Patel, Neha C. Bhoraniya, Priyanka Pankhaniya and D. M. Purohit

Abstract

We have synthesized (E)-N-{2’,4’-dibromo-6’-[3”-(aryl)-3”-oxoprop- 1”-en-1”- yl]phenyl}furan-2-carboxamides (3a-3l) and N-{2’,4’- Dibromo-6’-[3”-(aryl)isoxazol-5”- yl]phenyl}furan-2-carboxamides (4a-4l). The structure of the synthesized compounds proved by IR, 1HNMR, Mass spectra and TLC. The compounds (3a-3l) and (4a-4l) have been evaluated for their antimicrobial activity against Gram positive bacteria (Staphylococcus aureus, Bacillus subtilis), Gram negative bacteria (Pseudomonas aeruginosa, Escherichia coli) and Fungi (Aspergillus Niger). They are compared with known standard drugs.

Keywords: Chalcones, Isoxazoles, Antimicrobial activity.

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