Abstract

PREPARATION AND EVALUATION OF POLYHERBAL ANTIDIABETIC FORMULATION (CHURNA)

Aseeba Shirin M. K.*, Adithya P., Febin Farhan Arakkal, Huda Kareem, Dr. R. V Celestin Baboo and Dr. Sirajudheen M.K

.

Abstract

Diabetes is a long metabolic disease of the lipid, protein, and carbohydrate metabolism that is characterized by elevated postprandial blood sugar levels and increased fasting. The aerial parts of Clitoria ternatea, leaves of Psidium gaujava, leaves of Moringa oleifera and seeds of Trigonella foenum graecum are used in the present study for determining their anti-diabetic property. The aim of the present study is to formulate a polyherbal formulation as Churna and evaluate its antidiabetic potential using in-vitro chemical assay by alpha amylase inhibition method. The quality of polyherbal formulation was evaluated as per the guidelines of WHO. The study was conducted to investigate the alpha amylase inhibitory potential of prepared polyherbal formulation. The test sample and standard acarbose showed % alpha amylase inhibition of 23.49 %- 35.76 % and 20.19 % - 33.25 % on varying concentrations from 10-50 microgram/ml with an IC50 value of 31.2498 and 25.6689 respectively. Thus, our findings indicate that the prepared polyherbal formulation shows antidiabetic property and can be used in the treatment of Diabetes Mellitus.

Keywords: Diabetes, Ash Value, Alpha Amylase, Anti-diabteic activity.