Abstract

TRANSFEROSOMES: A NOVEL APPROACH FOR TRANSDERMAL DRUG DELIVERY SYSTEM

Aarti B. Ambhore, *Dr. Maria Saifee, Reshma Toshniwal, Pratiksha Kawade

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Abstract

Transferosomes are also known as the ultra deformable vesicles. It acts as a penetration enhancer due to its remarkable ability to penetrate deep into the skin layers and efficiently deliver therapeutic agents. This review provides a comprehensive overview of transferosomes, highlighting their structure, mechanism of action, and application in various fields, including pharmaceuticals, cosmetics, and biotechnology. The unique structure of transferosomes, comprising phospholipids bilayers with added edge activators, imparts them with flexibility and deformability, enabling them to squeeze through narrow pores and bypass biological barriers with ease. various techniques, such as ethanol injection methods, reverse phase evaporation, rotatory evaporation, and centrifugation methods, are employed for the preparation of transferosomes. each offering distinct advantages in terms of vesicle size, stability, and drug encapsulation efficiency. Various characterization s Transferosomes have immense potential to enhance the transdermal delivery of drugs. Particularly hydrophilic and macromolecule compounds that face challenges in permeating the skin permeating the skin barrier.by exploiting the flexibility of transferosomes. minimizing systemic side effects and improving patient compliance. Moreover, transferosomes find applications beyond pharmaceuticals, including the formulation of skin care products, where they enhance the delivery of active ingredients for improved efficacy in treating various dermatological conditions. Despite their immense potential, challenges such as stability during storage, and regulatory approval remain to be addressed for the widespread commercialization of transferosome-based formulations. Future research efforts should focus on optimizing fabrication techniques, exploring novel edge activators, and conducting extensive preclinical and clinical studies to validate the safety and efficacy of transferosome-based drug delivery systems. In conclusion, transferosomes represent a promising platform for overcoming barriers to drug delivery, offering enhanced therapeutics outcomes and expanded possibilities in pharmaceuticals, cosmetics, and biotechnology. continued advancements in this field hold the potential to revolutionize the way we administer therapeutics and address unmet medical needs.

Keywords: Transdermal drug delivery system, novel characterization, stratum corneum, mechanism action of transferosome, vesicular delivery system; phospholipid; edge activator. Methods of preparation, factors affecting.