Abstract

SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL OXAZINE AND THIAZINE DERIVATIVES AS POTENT ANTIMICROBIAL AND ANTIOXIDANT AGENTS

Battala Swapna*, Poosala Rajkumar, Y. Vinay Sree and Ch. Harini

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Abstract

Oxazines and Thiazines are the heterocyclic compounds in which oxazine containing heteroatoms (N&O) and thiazine containing heteroatoms (N&S) in a doubly bond un- saturated six-membered ring. The present investigation is about synthesis and evaluation of oxazine and thiazine derivatives as potent antimicrobial and antioxidants. Antibacterial is done against the Escherichia coli, Proteus vulgaris, Bacillus subtilis, Staphylococcus aureus, Lactobacillus acidophilus by cup plate method and medium was nutrient agar medium and Antifungal is done against the Aspergillus niger, Can- dida albicans, Malassezia fur fur by cup plate method and medium was sabouraud dex trose agar medium and Antioxidants is done by the 2,2-Diphenyl-1-picrylhydrazyl (DPPH) assay and Iron chelation method.

Keywords: Oxazine, Thiazine, Antimicrobial activity, Antioxidant activity.