Abstract

FORMULATION AND EVALUATION OF POLYHERBAL ANTIACNE CREAM

Suryam Gugulothu*, G. Shravani, Md. Ayazuddin, M. Sneha, N. Pravalika, P. Saikumar, Sridivya Chandragiri and Rajitha E.

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Abstract

Acne by definition is multifactorial chronic inflammatory disease of pilosebaceous units. Propionibacterium acnes and staphylococcus epidermidis are considered as the major skin bacteria that cause the formation of acne. Although acne does not pose serious threat to general health, it is one of the most socially distressing conditions especially for adolescents. In the present study, poly herbal anti acne cream was prepared using extracts of the plants Tulsi, aloe vera along with base materials. The plants have been reported in the literature having good anti- microbial, anti- oxidant and anti-inflammatory activity. Five formulations of the cream were prepared by varying the proportions of polymers and evaluated for their physicochemical property like pH, Spreadability, viscosity, homogeneity, appearance, after feel and spreadability like tests. Among the 5 formulations the formulations 3 and 4 shows better results in evaluation. The main objective is to prepare a cream with natural herbal extracts and minimize the side effects of the chemical cosmetics. Acne vulgaris is a common skin disorder which affects containing the most extensive oil glands, including the face, back and trunk. Propionibacterium acne, an anaerobic pathogen, plays an important Part in the pathogenesis of acne. It has also participated in the production of inflammatory acne by its ability to activate Antioxidants and metabolize sebaceous triglycerides into fatty acids, which draw neutrophils chemotactically. Acne is one of the most socially distressing skin disorders, particularly for teens, who have to cope with a disfiguring disease that erupts just When sexual maturity makes them maximum sensitive about their Appearance. Moreover, permanent scarring of the skin due to severe Acne leads to social distress throughout the entirely of adulthood. The modification and progress of acne is due to abnormal keratinocyte Proliferation and desquamation leading to ductal obstruction. Androgen driven sebum production enhances proliferation of P. acne. Excessive production of sebum block the pores and resulted in Inflammation. For many years, the use of antibiotics has shown Against vulgaris. Nevertheless, the prevalence of antibiotic resistance Within the dermatological setting has been increased. The progress of Antibiotic resistance is multi-factorial, including the specific nature of the relationship of the bacteria to antibiotics, how the antibacterial is used, host characteristics and environmental factors]. To avoid the problem of antibiotic resistance, researches on medicinal plants have been done as alternative treatment for the disease.

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