Abstract

DEVELOPMENT AND CHARACTERIZATION OF TAPENTADOL NANOGEL BY MODIFIED EMULSIFICATION TECHNIQUE

Karamcheti Sai Theja* and V. Leela Lakshmi

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Abstract

This study focuses on creating a new kind of tapentadol, a strong pain reliever, using a modified emulsification diffusion technique. The tapentadol will be in the form of a nano gel, and its design, development, and properties will be thoroughly examined. The nano gel was developed using a blend of polymers, namely Eudragit RL- 100, ethylcellulose, and Carbopol 934P, which were selected for their beneficial characteristics in drug delivery systems. The research used a modified emulsification diffusion technique to provide accurate control over the distribution of particle sizes. This approach improved the bioavailability and therapeutic effectiveness of tapentadol. The process involves emulsifying tapentadol in an appropriate organic solvent and then diffusing it into an aqueous phase containing the polymer mix while stirring under controlled conditions. The produced nano gel underwent extensive characterization testing. The physicochemical characterisation, which included analyzing particle size, measuring zeta potential, and examining shape using SEM, showed that tapentadol nanoparticles were evenly distributed inside the gel matrix. The rheological characteristics of the nano gel were assessed to determine its appropriateness for topical use. In addition, research on the kinetics of drug release showed that the nano gel formulation effectively and consistently released tapentadol, suggesting its ability to provide long-lasting pain relief. The stability investigations have proven that the formed nano gel is stable over a long period of time. Overall, the tapentadol nano gel created using the modified emulsification diffusion process using Eudragit RL-100, ethylcellulose, and Carbopol 934P has great promise for improving drug delivery and might be used effectively in pain treatment. This work enhances the progress of nano drug delivery systems to provide better therapeutic results.

Keywords: Tapentadol, Eudragit RL-100, ethylcellulose, and Carbopol 934P.