Abstract

A REVIEW ON TERATOGENICITY AND ITS CONSEQUENCES

Rohit Yadav*, Garima Carpenter, Meena Bandiya, Nilesh Kumar Pathak, Nishita Yadav and Dr. Darshan Dubey

.

Abstract

This review give a detail about teratogenecity, its prevention, detection and drugs which cause teratogenesity and some term related wih teratogenesis. Teratogenesis is a effect characterized by structural and functional defects in the developing embryo or foetus. Toxic chemical can kill some of the cell in the blastocyst, resulting in the death of embryo. During the postimplantation period, chemical-induced cell death leads to one of two outcomes. Since organogenesis occurs mostly in the embryonic stages, chemical exposure in the first trimester should be minimized, if possible. Little is known about mechanisms of teratogenesis. In 1941 the first well-documented cases of environmental agents being the cause of severe birth defects were report. As a baby grows in the womb, teratogens may affect parts of the baby’s body as they are forming. For example, the neural tube closes in the first 3 to 5 weeks of the pregnancy. Some organs are sensitive to teratogens during the whole pregnancy. This includes the baby's brain and spinal cord.

Keywords: Teratogenicity, Megalocephaly, Blastocyst, Legislation, Malformations, Congenital, Carcinogenesis.