Abstract

GASTRORETENTIVE DRUG DELIVERY SYSTEM - A REVIEW

Firdos Sultana*, Umamaheswari, Raziya Begum, Vasantha T. S.

.

Abstract

English oral delivery of drug was the commonly used modality because of patient compliance and ease of administration. After oral administration of any drug, its bioavailability is affected by its residence time in stomach. Recently, gastroretentive drug delivery systems (GRDDS) have gained wide acceptance for drugs with a narrow absorption window, decreased stability at high alkaline pH, and increased solubility at low pH. This approach develops a drug delivery system, which gets retained within gastric fluid, thereby releasing its active principles in the stomach.[1] A Controlled release dosage forms have been extensively used to improve therapy with several important drugs. However, the development processes are faced with several physiological difficulties such as the inability to restrain and localize the system within the desired region of the gastrointestinal tract and the highly variable nature of the gastric emptying process. This variability may lead to unpredictable bioavailability and times to achieve peak plasma levels.[2] The present study attempts to give an insight into the gastroretentive drug delivery systems, and gastric floating tablets, in particular. These have attracted the interest of many formulators due to their advantages over the conventional drug delivery systems.

Keywords: Novel drug delivery system, Gastroretentive, Bioavailability, gastric retention time, Therapeutics efficiency.