Abstract

“ENHANCED ORAL BIOAVAILABILITY OF IBUPROFEN BY A NOVEL SOLID SELF EMULSIFYING DRUG DELIVERY SYSTEM”

N. S. Dhavare, S. K. Bais and Balaji Yeldi*

Abstract

Nonsteroidal anti-inflammatory drugs, or NSAIDs, like ibuprofen, are commonly used because of their analgesic and anti-inflammatory qualities. Unfortunately, its therapeutic efficacy and bioavailability are restricted by its poor aqueous solubility. In this work, we developed a solid self-emulsifying drug delivery system (S-SEDDS) to improve ibuprofen's oral bioavailability. Ibuprofen, lipid excipients, surfactants, and co-surfactants were used to prepare the S-SEDDS formulation. Particle size, zeta potential, and morphology were some of the physicochemical characteristics that were assessed for the optimised formulation. To assess the ibuprofen dissolution profile of the SSEDDS formulation in comparison to a commercial ibuprofen formulation, in vitro dissolution studies were carried out. Moreover, oral bioavailability of ibuprofen from the S-SEDDS formulation in comparison to the commercial formulation was evaluated through in vivo pharmacokinetic studies conducted in rats. In comparison to the commercial formulation, the S-SEDDS formulation considerably increased the oral bioavailability and dissolving rate of ibuprofen, according to the studies. All things considered, our research indicates that solid self-emulsifying drug delivery systems are a viable means of increasing the oral bioavailability of poorly soluble medications, such as ibuprofen, which will increase their therapeutic efficacy and patient compliance.

Keywords: Self Emulsifying Drug Delivery System, Ibuprofen, Bioavailability, Solubility.