Abstract

MELATONIN SUPPLEMENTS - A NEW BOON FOR TREATMENT OF VARIOUS DISEASE/DISORDER

Sushruta Chakraborty*, Shyamacharan Banerjee, Surita Ghosh, Sujata Burnwal, Sumana Das and Bithika Banerjee

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Abstract

The paper provides a comprehensive overview of melatonin, a lipophilic hormone primarily produced in the pineal gland, highlighting its extensive therapeutic potential. Melatonin is known for regulating circadian rhythms, mood, sleep, and immune function. The hormone's synthesis from the neurotransmitter serotonin and its wide distribution across various body tissues, including the gastrointestinal tract, skin, and retina, are discussed. The paper explores melatonin's role in treating sleep disorders, particularly insomnia, and its efficacy in managing conditions like depression, anxiety, schizophrenia, and neurodegenerative diseases such as Alzheimer's and Parkinson's disease. Melatonin's antioxidant properties make it a potent agent against oxidative stress, contributing to its neuroprotective effects. Additionally, the hormone exhibits anti-inflammatory, anti-aging, and cancer-fighting properties. Melatonin's potential to enhance chemotherapy efficacy and mitigate its side effects is particularly noted. The paper underscores melatonin's safety and minimal side effects, making it suitable for long-term use. Future research directions include optimizing melatonin formulations and delivery methods to enhance its therapeutic efficacy and bioavailability, thereby maximizing its health benefits across various disorders.

Keywords: Melatonin, Nutraceuticals, Neurodegenerative disorder, Antioxidant, Anticancer.