Abstract

IN-VITRO AND THERAPEUTIC STUDY OF APIGENIN DERIVATIVE FOR THE CONTROL OF CANCER

Kasturi V. Sawarkar* and Puja K. Badne

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Abstract

Studying the in-vitro and therapeutic potential of apigenin derivative for cancer control is an exciting area of research in oncology. Apigenin is a naturally occurring flavonoid found in many fruits and vegetables, known for its antioxidant and anti-inflammatory properties. Researchers have been investigating its derivative due to their potential enhanced bioavailability and efficacy in targeting cancer cells. “In-vitro and therapeutic study of apigenin derivative” discusses the use of computational techniques in drug discovery and development, specifically focusing on preparing apigenin derivative for cancer control. The study involves molecular docking analysis using autodock vina software, with selected apigenin derivative showing higher affinity as inhibitors for RALGEF-RBD compared to a reference compound. The research highlights the potential of these apigenin analogues in inhibiting RALGEF-RBD activity and emphasizes the importance of computational tools in drug discovery. Additionally, the study confirms the non-toxic nature of the synthetic compounds and suggests that these derivatives may have the potential to become effective future drugs against various diseases, including cancer.

Keywords: Apigenin derivative, In-vitro, Therapeutic study, Cancer, ChemSketch software, Computational study, Novelty assessment, Drug design, Molecular docking, Target protein, 3D structure, Structure-based drug design, Ligand-based drug design, SMILES.