Abstract

A REVIEW ON NANOSUSPENSIONS: A NOVEL APPROACH TO ENHANCE SOLUBILITY OF DRUGS

Ankita Sharma, Jyoti Sharma, Prerna Thakur, Garima Kapoor, Ashish Kumar

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Abstract

One of the major problems associated with BCS (Biopharmaceutical classification system) class Ⅱ and Ⅳ drugs is poor aqueous solubility of drugs such as Simvastatin, carbamazepine, nifedipine, phenytoin, itraconazole, furosemide, paclitaxel etc. Low aqueous solubility of drugs leads low bioavailability of drugs. Therefore, formulation of drug in form of nanosuspension is a good alternative to solve these problems and considered as promising strategy for efficient delivery of hydrophobic drugs. Nanosuspensions are prepared by using various technologies such as top down technology, bottom up technology, emulsion diffusion method, microemulsion template and supercritical fluid method. The reduction of particle size of drug into submicron level leads to increase in dissolution rate of drug, improves therapeutic efficacy, increases the bioavailability and reduce the toxicity of drug. Nanosuspensions can be delivered by various routes of administration such as oral drug delivery system, topical drug delivery system, mucoadhesive drug delivery system. This review describes the method of preparation, evaluation and applications of nanosuspensions.

Keywords: Nanosuspension, poorly soluble drugs, bioavailability, solubility, homogenization.