Abstract

FABRICATION AND CHARACTERIZATION OF AMOXICILLIN TRIHYDRATE IP LOADED MICROBEADS FOR GRDDS

Dr. Praveen Kumar Ashok, Dr. Yogita Tyagi, Ms. Hiba Parveen and Mani Ratnam Bhardwaj*

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Abstract

The main aim of present research work is to develop gastro retentive drug delivery systems of Amoxicillin trihydrate. The impact of Carbopol 940 in HPMC different grades in matrix formation demonstrated in this work. The swelling property and controlled drug release profile also analysed comprehensively. The floating tablets of Amoxicillin trihydrate was developed to achieve a site specific drug delivery. The reason for developing Amoxicillin trihydrate as floating drug delivery systems is to treat Helicobacter pylori infections in stomach. It is desirable to treat the infection in the stomach. The dosage form releases more amount of drug in the stomach which offers better therapy than conventional tablets. The purpose of this investigation was to design and develop floating microspheres of Amoxicillin Trihydrate by ionotropic gelation method with combination of two polymers and to get the best possible formulation out of that with the various aspects. Floating drug delivery system have a bulk density less than gastric fluids and so remains buoyant in the stomach without affecting gastric emptying rate for a prolonged period of time. The formulations were designed by using various grades of hydroxyl propyl methylcellulose polymers (HPMC K4M and E15LV) and Carbopol 940. The excipients such as sodium Bicarbonate, citric acid also incorporated in the formulation as gas forming agent. The in vitro studies were analysed by various pharmacokinetic models. The swelling index, buoyancy lag time and total floating time were also reported in this work.

Keywords: Amoxicillin Trihydrate, HPMC E15 LV, HPMC K4M, Carbopol 940, Microspheres, Ionotropic Gelation Method, Ethyl cellulose, Hydroxy propylmethyl cellulose.