Abstract

FORMULATION, DEVELOPMENT AND EVALUATION OF CELERY EXTRACT CAPSULES DELIVERY SYSTEM AS AN ADVANCED PHYTOTHERAPY APPROACH FOR GOUT

Prof. Dr. Mahmoud Mahyoob Alburyhi* and Prof. Dr. Amina El-Shaibany

Abstract

Gout is an inflammatory arthritis that belongs to a group of arthropathies called the „crystalline arthropathies‟. Gout is caused by a robust inflammatory response to uric acid crystals which occurs in the setting of hyperuricemia. Supersaturation of uric acid can lead to crystal accumulation and deposition in the joints and tissues to which the immune system reacts. Uric acid tophi appear as hard nodules under the skin and can cause considerable destruction and discomfort. Celery is widely used throughout the world. Some of their pharmacological properties include anti-inflammation, goutrheumatism arthritis, antioxidant, aphrodisiac, anthelmintic, antispasmodic, carminative, diuretic, emmenagogue, laxative, sedative, antimicrobial, hepatoprotective, appetizer, antiasthma, anti-bronchitis, anticancer, antifungal, nematocidal, anticonvulsant, breast milk inducer, anti-jaundice, antihypertensive, anti-dysmenorrhea, spermatogenesis induction and prevention of cardiovascular diseases. In the present study the Celery extract was formulated and evaluated as capsules. It was concluded that among the all formulations of Celery extract capsules the F1 was found to be as an optimized capsules according to drug release percentage 96% within 45 minutes, so the F1 was the best formulation of Celery extract capsules delivery system as an advanced phytotherapy approach for gout.

Keywords: Celery, Extract, Capsules, Antigout, Phytotherapy.