Abstract

RECENT ADVANCEMENTS IN PROGESTERONE DELIVERY SYSTEMS

Aniket Neelesh Timble*, Akshay Nitin Deo and Khushal Bisan Rathod

Abstract

The human body naturally secretes progesterone, a steroidal sex hormone, through the ovary, placenta, and adrenal cortex. Progesterone is necessary for the endometrium to change in the uterus during ovulation and to maintain pregnancy in humans. Progesterone is given through a variety of methods, including oral, vaginal, transdermal, topical, parental, and intranasal, when the body is unable to manufacture enough of it for a particular condition. The main obstacles to progesterone distribution are its poor solubility, limited permeability, and significant hepatic first-pass metabolism, despite the fact that it is commercially available in a variety of standard formulations. Progesterone can be effectively delivered by innovative methods such as lipid carriers, polymeric carriers, hydrogels, multiple nanocarriers, depot, and controlled release systems. Over the past 20 years, a number of research publications and patents on progesterone administration methods have been published; safety and efficacy were established through clinical investigations. The progesterone pharmacodynamic and pharmacokinetic factors, delivery limitations, and enhanced progesterone delivery technologies are the main topics of this paper.

Keywords: Progesterone, Contraceptive, Novel delivery systems, Delivery constraints, Pharmacokinetic parameters.