Abstract

“AN EVALUATION OF INTRAVENOUS TO ORAL CONVERSION OF STEROIDS USED IN PULMONARY WARD IN A TERTIARY CARE HOSPITAL”

Dr. Aishwarya Joshi*, Dr. Ishika Soni*, Dr. Jaswant Singh Shaktawat*, Dr. Jeshurun Mathew James*, Dr. Jai Singh Vaghela*, Dr. Manoj Vasudev Jani*

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Abstract

Adrenal glands produce essential hormones like cortisol and aldosterone, which are synthesized into corticosteroids to reduce inflammation. Various steroids, including prednisolone (tablets), beclomethasone and fluticasone (inhalers/nasal sprays), methylprednisolone (injection), and hydrocortisone (creams), are widely used to treat conditions such as asthma, COPD, and bronchiectasis. However, these steroids can also suppress the immune system. This study aims to compare the conversion of intravenous (IV) and oral steroids in 100 patients with asthma, COPD, and bronchiectasis using a paired t-test. Methylprednisolone was commonly administered orally, while hydrocortisone was given intravenously. All patients received budesonide. Approximately 7% of the patients experienced insomnia and 5% reported appetite disruption. The average duration of IV treatment was 3.72 days for methylprednisolone and 3.66 days for hydrocortisone. The results indicated a p-value of less than 0.05 in all tables, leading us to reject the null hypothesis. Therefore, we conclude that there is a significant difference between the two groups.

Keywords: Alpha-1 antitrypsin deficiency (AAT), Chronic obstructive pulmonary disease (COPD), HIV (Human Immunodeficiency Virus), High resolution computed tomography (HRCT), inflammatory bowel disease (IBD), ICS (Inhaled Corticosteroids), IPF (Idiopathic Pulmonary