Abstract

REVIEW ON RECENT ADVANCEMENTS IN TECHNOLOGIES FOR OPIOID ABUSE-DETERRENT FORMULATIONS AND REGULATORY REQUIREMENTS

Viratkumar Khatri* and Prayag Raval

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Abstract

Chronic pain arises from several diseases and conditions. The issue of inappropriate utilization of crucial opioid medicine has been a subject of significant discussion over the past two decades, particularly in relation to its use for long-term management of chronic pain. Abusedeterrent formulations are essential components of comprehensive strategies for mitigating the dangers associated with opioids. These formulations reduce the attractiveness and addictive characteristics of opioids by limiting their ability to be absorbed by the body. This reduces the attractiveness and motivations for abusing modified opioid prescriptions, and also presents difficulties in extracting the opioid component for use in different ways. This article analyzes several regulatory measures, anticipated requirements for obtaining licenses for abuse-deterrent formulations, and ongoing efforts to develop opioid abuse-deterrent formulations as potential solutions to address the opioid abuse epidemic. Given the gravity of the worldwide opioid crisis, it is imperative for different regulatory bodies to collaborate in order to protect society from the opioid pandemic. This entails the implementation of a comprehensive policy for the prescription of opioid medications to patients, the conduction of evaluations to assess the probability of addiction, and the enhancement of efforts to approve only opioid drugs that are specially designed to mitigate abuse.

Keywords: Abuse, Abuse Deterrent Technology, Opioid, Overdose, Regulatory.