Abstract

REVIEW THE LATEST DEVELOPMENTS IN THE DRUG DELIVERY SYSTEM INCLUDING THE NANOPARTICLES AND THEIR APPLICATION IN IMPROVING DRUG BIOAVAILABILITY AND PATIENT COMPLIANCE

Anita G. Rathod* and Poonam D. Awaghate

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Abstract

Nanoparticle-based drug delivery systems have emerged as a promising approach to address the limitations of conventional drug formulations, particularly in terms of improving drug bioavailability and enhancing patient compliance. This abstract reviews the latest developments in nanoparticle technology and its applications in pharmaceutical research and development. Recent advancements in nanoparticle formulations, including liposomes, polymeric nanoparticles, dendrimers, and solid lipid nanoparticles, have facilitated the encapsulation of drugs, protecting them from degradation and enabling controlled release. These formulations have demonstrated the ability to enhance drug solubility and stability, leading to improved bioavailability and therapeutic efficacy. Targeted drug delivery using functionalized nanoparticles has gained significant attention for its potential to selectively deliver drugs to specific tissues or cells, minimizing systemic side effects and maximizing therapeutic outcomes. Stimuli-responsive nanoparticles, capable of releasing drugs in response to environmental cues, offer precise control over drug release kinetics, paving the way for personalized medicine approaches. Moreover, nanoparticle-based drug delivery systems have shown promise in improving patient compliance by offering convenient dosing regimens and reducing the frequency of drug administration. Long-acting nanoparticle formulations have the potential to enhance adherence to treatment regimens and optimize therapeutic outcomes, particularly for chronic conditions.

Keywords: Nanoparticle formulation, Improved drug bioavailability, Targeted drug delivery, Control Release system, improved patient compliance.