Abstract

FORMULATION AND EVALUATION OF SUMATRIPTAN NIOSOMAL SUSPENSION FOR ANTIMIGRAINE ACTIVITY

Aniket V. Chandankhede*, Rajashree S. Chavan, Jitendra V. Shinde, Vinayak D. Patharwat, Radhika U. Mane and Gaurav V. Tekade

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Abstract

Sumatriptan is an antimigraine agent and Serotonin receptor agonist belonging to the class of drugs called Triptans and used in the treatment of Migraine attacks. It has short half-life of 2.5 hrs and low oral bioavailability (14%) due to extensive first pass metabolism. Objective: The oral route has several advantages viz., large surface area, high blood flow, ease of administration that leads to faster and higher drug absorption. Keeping these facts in mind, the objective of the present study was to develop Sumatriptan loaded niosomal suspension. Method: Sumatriptan niosomal Suspension was formulated, optimized and evaluated with the objective to deliver drug to the brain via oral route. Niosomes were prepared by Ether injection method and optimized using 32 factorial designs. Niosomal suspension were characterized for Drug content, Particle size, Zeta potential, Entrapment efficiency and In-Vitro drug release etc. Result: The vesicle size of all niosomal suspension batches ranges between 223.04 to 650.46 nm. The vesicle size of optimized niosomal suspension A5 batch is 406.2±102.1nm. For A5 batch, the value of Zeta potential was found to be -32.3 mV; this specifies that prepared niosomes have sufficient surface charge to prevent aggregation of the vesicles. % entrapment efficiency for all batches was found in the range 86.4±0.7% to 96.3±0.3%. The cumulative percent release of niosomal suspension ranges from 84.24±0.39 to 94.31±0.26%. The SEM and Zeta potential studies showed the formation of stable vesicles. Conclusion: Thus, the application of niosomes proved the potential for oral delivery of Sumatriptan over the conventional formulations. Overall oral drug delivery for Sumatriptan has been successfully developed.

Keywords: Brain delivery, Sumatriptan, Absorption, Entrapment efficiency, Niosomal Suspension.