Abstract

ADVANCEMENT IN EXCIPIENTS THAT ARE USED IN ADDITIVE MANUFACTURING (3D PRINTING)

Siddhesh Sunil Tamboli*, Khushal Bisan Rathod, Aniket Neelesh Timble and Akshay Nitin Deo

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Abstract

The evolution of additive manufacturing (3D printing) has revolutionized various industries, including pharmaceuticals, by enabling the production of complex, customized, and high-precision structures. A critical aspect of this advancement is the development of novel excipients tailored for 3D printing technologies. Excipients, traditionally used as inert substances in drug formulations, have now been optimized to enhance the printability, stability, and functionality of 3D-printed products. This abstract reviews recent progress in excipient innovation, focusing on materials such as polymers, lipids, and biocompatible composites. Innovations include the modification of polymers like polyvinyl alcohol (PVA) and polyethylene glycol (PEG) to improve solubility and mechanical strength, the use of biopolymers like alginate and gelatin for bioprinting, and the integration of smart excipients capable of responding to environmental stimuli. The paper highlights how these advancements have expanded the capabilities of 3D printing, allowing for the creation of dosage forms with controlled release profiles, enhanced bioavailability, and personalized medicine applications. The implications of these developments suggest a transformative impact on the pharmaceutical manufacturing landscape, paving the way for more efficient, precise, and patient-specific therapeutic solutions.

Keywords: Additive Manufacturing, 3D Printing, Excipients, Polymers, Bioprinting, Pharmaceuticals, Customized Dosage Forms, Controlled Release, Personalized Medicine.