Abstract

COMPARATIVE ANTIBACTERIAL ACTIVITY OF NUTMEG SEED AND CINNAMOMUM BURMANII STEM BARK EXTRACT AGAINST STAPHYLOCOCCUS EPIDERMIDIS

Sri Agung Fitri Kusuma*, Ana Indrayati, Mulyati, Ronato and Danni Ramdhani

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Abstract

Objective: This study was aimed to compare the antibacterial effect of nutmeg seed and Cinnamomi burmanii stem bark extract against Staphylococcus epidermidis ATCC 13228. Methods: Nutmeg seed and C. burmanii stem bark were macerated in the 70% ethanol as the solvent. Then both extract's secondary metabolites were analyzed using a standard method. The antibacterial activity of both samples extract was evaluated on the growth of S. epidermidis in vitro using the agar diffusion method. Then, minimum inhibitory concentration (MIC) values of both extracts were determined using the broth dilution. Results: C. burmanii stem bark extract demonstrated higher antibacterial potential than the nutmeg seed extract against S. epidermidis in the MIC/MBC values of range 0.15625 to 0.3125 %w/v for C. burmanii and 0.3125 to 0.625%w/v for nutmeg seed. Conclusion: C. burmanii stem bark extract was recommended as antibacterial agent for S. epidemidis infection.

Keywords: Cinnamomum Burmanii, nutmeg, extract, antibacterial, Staphylococcus epidermidis.