Abstract

TUBERCULOSIS THERAPEUTICS REDEFINED: MERGING NANOMEDICINAL INNOVATIONS WITH TRADITIONAL PREVENTION TACTICS

Mohd. Alam*, Insharah Khan, Mohd. Farhan Shehzad, Hannan Husain, Abhijith Murali and Smriti Tiwari

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Abstract

Tuberculosis is a persistent infectious ailment instigated by the Mycobacterium tuberculosis bacterium, primarily impacting the lungs but with the capability to disseminate to other bodily organs. Despite worldwide initiatives, tuberculosis persists as a predominant cause of mortality globally, disproportionately affecting nations with low and middle incomes. Factors such as destitution, undernourishment, tobacco consumption, HIV/AIDS, and drug resistance contribute to the endurance of this disease. Natural substances have played a pivotal role in the pursuit of novel anti-tuberculosis medications, with the medicinal plant Azorella compacta exhibiting promising antimycobacterial properties. This review elucidates the global burden of tuberculosis, its risk factors, obstacles in treatment, and the potential of natural products like A. compacta in developing new therapeutic strategies to combat this deadly disease.

Keywords: Tuberculosis, Mycobacterium tuberculosis, worldwide health, drug resistance, Azorella compacta, anti-mycobacterial activity.