Abstract

FORMULATION AND EVALUATION OF HERBAL ORALLY DISINTEGRATING FILM FOR ORAL CANDIDIASIS

Vicky Chaurasiya*, Vivek Bhoir, Soniya Bhundere, Yashwant Chauhan, Kusum Chavan and Prashant Jagadhane

Abstract

Oral candidiasis is a fungal infection caused by the overgrowth of Candida species, typically Candida albicans, in the mouth and throat. This study focuses on the formulation and evaluation of a herbal orally disintegrating film containing Liquorice and Oregano, demonstrating its potential as a convenient and effective therapeutic option. The formulations (F1-F6) share a consistent use of HPMC K100 as the polymer, propylene glycol as the plasticizer, stevia as the sweetener, and distilled water as the solvent. However, they differ in their active ingredients and their quantities. The formulated films exhibited desirable physicochemical properties such as uniformity in thickness, weight variation, and mechanical strength and disintegration time, indicating their suitability for oral administration. Furthermore, in vitro drug release studies revealed the release of active constituents from the films, suggesting prolonged therapeutic efficacy and enhanced bioavailability. This antimicrobial activity is due to presence of bioactive compounds glycyrrhizin, carvacrol and thymol, have been reported to possess antifungal properties against Oral candida. The developed formulations offer several advantages including rapid disintegrating, excellent physical characteristics, bio adhesive properties, and potent antifungal activity, thereby holding great promise for clinical translation and future therapeutic applications.

Keywords: Orally Disintegrating Film, Oregano, Liquorice, Oral Candidiasis, Fast Dissolving Film.