Abstract

THE ROLE OF CEFUROXIME-AZELAIC ACID COMBINATION IN RESISTING ANTIBIOTIC RESISTANCE IN DERMATOLOGY

Anchal Jaiswal, Ran Vijay Singh and Sanjay Kumar Kushwaha*

Abstract

The evolving landscape of dermatological treatments necessitates innovative approaches to manage complex skin conditions effectively while addressing the challenge of antibiotic resistance. This review explores the potential of combining cefuroxime, a broad-spectrum cephalosporin antibiotic, with azelaic acid, a dicarboxylic acid with antimicrobial, anti- inflammatory, and comedolytic properties, for dermatological therapy. The theoretical synergy between cefuroxime's bactericidal action and azelaic acid's ability to treat inflammation and non- antibiotic-resistant microbial strains offers a comprehensive treatment strategy. This combination could enhance the efficacy of dermatological treatments, reduce the development of antibiotic resistance, and maintain a favorable safety and tolerability profile. However, the lack of direct clinical evidence on the combined use of cefuroxime and azelaic acid highlights a significant gap in current dermatological research. This review discusses the potential benefits, challenges, and limitations of this combination therapy, emphasizing the need for future clinical trials to establish evidence-based guidelines for its use in practice. The exploration of patient outcomes and experiences with this therapy could further inform its clinical application, ensuring optimized treatment strategies for complex dermatological conditions.

Keywords: Cefuroxime, Azelaic Acid, Dermatological Therapy, Antibiotic Resistance, Combination Therapy, Clinical Trials.