Abstract

FORMULATION AND EVALUATION OF HERBAL EMUGEL FOR ANTIACNE ACTIVITY

Rathod Mohini*, Siddhi Parmar, Parkhiya Divyen, Vishesh Parikh and Vivek Patel

Abstract

Bacterial infections continue to pose significant threats to public health globally, leading to morbidity and mortality across diverse populations. Drug distribution through the skin is an effective treatment for bacterial infections, a frequent dermatological issue. Emugel is a novel drug delivery system that enables the controlled release of emulsion and gel for topical use. Mixing an emulsion into a gel increases its stability. In the current investigation, emulgels containing extracts of neem leaf, neem fruit oil, and peepal extract were created to treat Bacterial skin infections. neem leaf contains chemicals that constitute sugiol, nimbiol, triterpenes, stigmasterol, limonoids, nimodipine, nimbendiol, nimton. Neem fruit oil contains limonene, borneol, α- ionone, cis-β-guaiene, β-caryophyllene, carveol, and p-cymene which is utilized to generate an oil phase, which effectively stabilizes the emulsion. Initially, emulsions using the extract were made with emulsifying agents such as tween 20 and span 20. Emulgels were created by combining prepared emulsions with carbopol 934 and Na CMC at a 1:1 ratio with the help of carbopol 934 and Triethanolamine. Different formulations (F1&F2) were prepared using different ratios and different evaluation parameter such as pH, Physical appearance, stability, spreadbility and antibacterial properties were checked. All formulations produced satisfactory results for tested parameters. The result indicates formulation F2 has Better spreadability, Stability, and antibacterial properties than the other formulation. After examining these parameters, it was concluded that neem oil-based emulgel with neem and peepal leave extract can effectively cure bacterial infections on the skin along with cosmetic benefits.

Keywords: Emulgel, Neem leaf extract, Peepal leaf extract , Neem fruit oil, Antibacterial activity.