Abstract

REVIEW OF DIOSPYROS MALABARICA EXTRACT AND ITS POTENTIAL WOUND HEALING ACTIVITY IN MICE

Pooja Thakur*, Sangeeta Singh and Sunil Kumar

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Abstract

The animal body weight, food, and water consumption did not alter when they were given 2000 mg/kg of body weight, according to the findings of this study. Even at the highest treatment level, 2000 mg/kg fresh plant material no mortality was observed, and no significant alterations in histological parameters were seen. This shows that Diospyros malabarica plant material has no significant harmful effect in male albino mice at dose levels up to 2000 mg/kg. It is mentioned that two bioactive flavonoids and phytosterols have been identified successfully from the ethanolic leaves extract of Diospyros malabarica under the present study. Based on the pre-phytochemical investigation, thin layer chromatography, and spectra data analysis, the compounds were identified as Flavanols, Luteolin, Quercetin, and β- Sitosterol. This study emphasizes the importance of further research to better define the roles of Diospyros malabarica consumption that may be responsible for the beneficial effects. An assessment of whether the cited effects in mice parallel those in humans would be no less difficult, but potentially beneficial for human health. To summarize the findings of this study, it was discovered that a methanolic extract of Diospyros malabarica converted into an ointment formulation has wound healing activity.

Keywords: Diospyros Malabarica, Wound, Regeneration, Deserpidine & Tridax procumbens.