Abstract

BLOOD STORAGE LESIONS AND OTHER BIOCHEMICAL CHANGES ASSOCIATED WITH DONOR BLOOD

*Obeagu Emmanuel Ifeanyi, Okoroiwu, I.L.

Abstract

This paper reviewed lesions and some biochemical changes associated with stored Packed red blood cell in transfusion medicine. There are some biochemical changes and lesions that develop in stored blood.There is a decrease in 2,3-DPG levels in stored blood which maintain the integrity of red blood cell. There is also gardual decrease in ATP level which affect every energy-dependent process which the cell may want to conduct. The absence of ATP results in dysfunction of ion pumps and other membrane proteins, which in turn results in all sorts of impaired mechanisms, most notably the maintenance of red blood cell shape. There is change fom normal shape of red blood cell to abnormal shape. There is haemloysis and release of free haemoglobin. There is also accumulation of metabolic byproducts and proinflammatory molecules. Packed red blood cell should be transfused young irrespective of the anticoagulants. The viability of the transfused cells should be ensured for general well-being of the patient.

Keywords: Lesions,2,3-DPG,ATP,Ion pumps,Membrane proteins,Free haemoglobin.