Abstract

DEVELOPMENT AND IN-VITRO RELEASE STUDY OF NANOEMULSION OF CURCUMIN

Dr. Kalyan Kumar Sen*, Sugata De Joarder, Shubhashis Mandal, Suman Mandal and Pradip Santra

Abstract

Submicron-sized emulsions known as nano emulsions are being studied as medication carriers to enhance the delivery of medicinal medicines. These are the thermodynamically stable isotropic systems when the right cosurfactant and surfactant are used to combine two immiscible liquids into a single phase. The average range of nano emulsion droplet sizes is 20-200 nm, with a limited size distribution. This review focuses on providing a brief overview of the formulation aspect, the method of preparation, characterization techniques, evaluation parameters, and various applications of nano emulsions. Various techniques, such as solvent evaporation, high pressure homogenization, micro fluidization, and low energy emulsification, are used to prepare nano emulsions, and parameters such as droplet size analysis and viscosity determination are used to characterize them. Oil-in-water (o/w) emulsions with mean droplet sizes ranging from 50 to 1000 nm are referred to as nano emulsions. Droplet sizes typically range from 100 to 500 nm, and the words mini-emulsion and submicron emulsion (SME) are interchangeable. Three varieties of nano emulsions have been created since the 1940s: continuous, water-in-oil (W/O), and oil- in-water (O/W). It is possible to convert between these three varieties simply changing the emulsions' constituent parts. Many techniques have been used to look into the mechanism of nano emulsion generation and stability. While some theories (solubilization theories) highlight the monophasic environment of the various nano emulsions, others (mixed film theories) highlight the formation of the interface film and the production of extremely low interfacial stress. Methods of preparation of nano emulsions The preparation of nano emulsions can be carried out either by high energy dissipation or low energy dissipation method. These twomethods differ by the amount of energy used. The high energy method uses mechanical devices to generate large disruptive forces. Whereas, low energy method alters the physiochemical properties of the system to generate nanosized particles. Nanotechnology and nano emulsions Nanotechnology is a global concept that entails the manipulation of particles within the range of 10–1000 nm using scientific, innovative and well-characterized techniques, for improved productivity and applications in agriculture, healthcare, cosmetics, defines, energy and food sectors. The world’s nanotechnology industry could worth 80 billion US dollars and could be reaching 17% growth rate by 2024. Therefore, the potential benefits and profits are huge in this emerging market. Application of the technology to the food industry has always been towards emulsions, encapsulation and packaging technologies, of which nano emulsions are of utmost economic importance.

Keywords: Whereas, low energy method alters the physiochemical properties of the system to generate nanosized particles.