Abstract

CUBOSOMES: A FIRST GLANCE AT A NOVEL DRUG DELIVERY SYSTEM

Priti H. Jadhao*, Rampal P. Jadhao, Sudharshan E. Behere, Pravin S. Kawtikwar and Vilas N. Deshmukh

Abstract

Cubosomes are square and rounded particles that self-assemble, are nanostructured, thermodynamically stable, and have visible cubic lattices. These versatile systems can be administered orally, percutaneously, or parenterally due to their unique properties. Cubosomes are three-dimensional honeycomb structures made of curved bicontinuous lipid bilayers divided into two parts. Various bioactive ingredients, such as chemical drugs, peptides, and proteins, can use the internal aqueous channels. Cubosomes are stable at any dilution level due to the insolubility of the cubic phase forming lipid in water, making them easily incorporated into product formulations. This article provides an overview of cubosomes, including their structure, classification, properties, components, forms, preparation methods, and applications.

Keywords: Cubosomes, Components, Methods of preparation applications.