Abstract

FORMULATION, DEVELOPMENT & CHARACTERIZATION OF TRANSDERMAL PATCHES FOR CONTROLLED DELIVERY OF METFORMIN HYDROCHLORIDE TO IMPROVE DRUG BIOAVAILABILITY VIA TRANSDERMAL ROUTE

Dr. Praveen Ashok, Dr. Yogita Tyagi, Hiba Parveen and Monu Kumar*

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Abstract

The main objective of the this study was to formulate, develop and evaluate a Transdermal drug delivery system containing Metformin hydrochloride to overcome the critical problems related with oral route. Transdermal patch of Metformin hydrochloride were prepared using solvent evaporation technique. Different trial of formulation were carried out by changing the polymer ratio. Transdermal Patch formulations were characterized for Thickness, weight variation, Percentage Moisture content, Folding endurance, Assay and In vitro drug release studies. The purpose of this research was to determine whether or not the polymeric combinations of HPMC and ethyl cellulose could be used to create an effective matrix-type transdermal drug delivery system (TDDS) of MetforminHCL (EC). In a solvent system of dichloromethane and methanol (1:1), 6 matrix patches were produced employing these polymeric materials with propylene Glycol as a plasticizer and vegetable oils (eucalyptus oil) as permeation enhancers. Weight, medicament content, water content, hydration uptake, flatness, folding durability, and thickness were all measured and analysed to describe the formulations. Scanning electron microscopy (SEM) of the generated TDDS were recorded to see the drug - delivery pattern, and the stability of the preparations and in vitro dissolution of the trial formulations were utilized to calculate the quantity of metformin HCL in the patches.

Keywords: Transdermal Delivery, Metformin Hydrochloride, Topical Drug Delivery.