Abstract

FORMULATION AND EVALUATION OF CLOTRIMAZOLE TOPICAL EMULGEL

Kshitij Salve*, Sandip Shinde, Pranjal Shirsath, Prathmesh Shirsath, Sumit Sonawane

.

Abstract

Topical drug delivery systems are dosage forms that are applied to the skin when other routes of drug delivery fail or occur in skin diseases. Tropical drug delivery systems have the advantage of negotiating firstpass metabolism. It also helps to avoid the risks and inconveniences of I.V therapy. The main advantages of tropical drug delivery systems are avoidance of first-pass metabolism, avoidance of gastrointestinal incompatibility, specific site selectivity, improved patient compliance, possible and easy self-medication, short half-life and narrow therapeutic index. The function is used to easily terminate the medication if necessary. Disadvantages of topical drug delivery systems are skin irritation in contact dermatitis, allergic reactions, poor drug permeability through the skin, and large particle size drugs are not easily absorbed through the skin. Emulgels are oil-in-water or waterin- oil emulsions that are gelled by mixing with a gelling agent. Emulsifying gels are excellent stable vehicles for hydrophobic or poorly water-soluble drugs. In simple words, emulgel is a combination of emulsion and gel. Emulgel is manufactured as both an oil-in-water and waterin- oil emulsion mixed with a gel. Oil-in- water is used for lipophilic drugs and water-in-oil is used for hydrophobic drug delivery. Commercial emulgels include Cataflam emulgels, Denacin emulgels and Dicromax emulgels.

Keywords: Topical Drug Delivery System, Emulgel, Clotrimazole.