Abstract

DESIGNING AND ASSAYS OF POLYHEDRAL DUSTING POWDER WITH ANTIMICROBIAL PROPERTIES FOR MANAGING SKIN ITCHING

Dipmala Ghorpade, *Sujit Rakde, Akash Chavan, Aniket Bankar, Saurabh Wakle, Rohit Lahane and Gajanan Sanap

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Abstract

Pharmaceutical Industry Focus on Airborne Hazards: Pharmaceutical companies are increasingly prioritizing the development of potent, selective drugs, which has led to a heightened awareness of the potential airborne risks associated with hazardous ingredients. This trend extends beyond the pharmaceutical sector, impacting any industry handling powdered materials. Dustiness concerns are not limited to operational challenges; they also encompass worker health, the risk of plant explosions, and the prevention of product loss. 2. Testing and Therapeutic Potential: In vitro antimicrobial testing utilizing the agar diffusion method revealed significant effects on tested organisms. Additionally, phytochemical analysis of three leaves identified the presence of tannins and alkaloids, indicating potential therapeutic benefits. This suggests that a powdered formulation derived from these leaves could hold promise for treating skin infections and itchiness. 3. Preparation and Evaluation of Dusting Powder: The dusting powder was prepared by mixing all ingredients in a mortar and pestle. Various parameters including physical characteristics (color, odor, grittiness, appearance), solubility, pH, and micromeritic properties such as particle size, surface area, and density (bulk, tapped) were evaluated. Additionally, tests for antimicrobial activity against Escherichia coli and Staphylococcus aureus were conducted using a mix culture of these microorganisms via the well diffusion cup plate method. The efficacy of the formulation was assessed based on the inhibition zone surrounding the formulation after incubation. 4. Antimicrobial Testing and Conclusion: The sample, prepared by dissolving 1gm of powder in 10ml of water, was transferred to solidified agar media and streaked with bacterial culture. Following incubation at 37°C for 48 hours, the growth of microbes and their inhibition zones were observed and measured. The formulation exhibited specific effectiveness against microbial strains, particularly due to the presence of essential oils which showed high activity against E. coli and S. aureus. In conclusion, the polyherbal dusting powder demonstrated significant antimicrobial activity and warrants further exploration for the treatment of various topical skin diseases.

Keywords: Polyherbal Dusting Powder, Dermal Pruritus, Antimicrobial Properties, Skin Irritation.