Abstract

IMMUNOHISTOCHEMISTRY PROFILE OF FEMALE BREAST CANCER IN BASRAH CITY FROM (2021-2023) SCIENTIFIC COUNCIL OF THE ARAB BOARD OF ANATOMIC PATHOLOGY

* Dr. Asraa Abdulkareem Kamil and Dr. Wassan Mansour Al-alawi

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Abstract

receptors and Her2neu receptors expression which have significant inference for prognosis. Aim: The study aim to evaluate the hormonal receptor status in female breast cancer and assess the relationship with cancer grade and type. Methodology: Atotal 500 Cases of breast cancer were collected from governmental and private laboratories reports were collected; the study period was conducted from January 2021 to December2023. Data analyzed according to age, grade, histological type and immunohistochemical profile. Recurrent cases and cases with incomplete information were not included in the analysis. Results: Invasive ductal carcinoma (not otherwise specified) accounted for 94.2% of all cases in our analysis, with the majority of patients (32%) being between the ages of 51 and 60. The majority of these cases were grade III. Hormone receptor positivity was found to have an inverse relationship with HER 2/neu status. Compared to Grade ΙΙΙ tumors, the majority of low-grade cancers were ER+PR+. Conclusion: There was a significant statistical association (p=0.003) between the grade of breast cancer and (ER, PR, Her2neu). When the possibility of statistical association between type of cancer and (ER, PR, Her2neu), it was found that there was no any significant statistical association between the two factors (p=0.277), may be because not all cases of breast cancer with different histopathologic subtypes were included in this study.

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