Abstract

PREPARATION AND EVALUATION OF HERBO COOL HYDROGEL SHEET: A NATURAL DEFENCE AGAINST HERPES VIRUS

Anish Singh*, Samidha Shirke, Karan Singh, Shraddha Tambe, Riddhi Tandel and Sheetal Mahajan

Abstract

Herpes simplex virus (HSV) infections are a significant public health issue, with traditional treatments often leading to drug resistance and adverse side effects. This has driven research into natural and herbal alternatives, such as the Herbo-cool hydrogel sheet. This hydrogel sheet was created using a blend of herbs, including oatmeal extract, garlic extract, and cucumber extract, all known for their antiviral, antiinflammatory, and wound-healing properties. To enhance its mechanical strength and elasticity, the hydrogel underwent a freezethaw cycle. Its physicochemical properties were analyzed using scanning electron microscopy (SEM). In vitro antiviral assays demonstrated a significant reduction in HSV replication following application, indicating the hydrogel's potent antiviral properties. Cytotoxicity tests on human skin cell lines confirmed its safety. The hydrogel sheet's wound-healing capabilities were evaluated in an animal model, showing faster re-epithelialization and reduced inflammation. Stability and shelf-life studies indicated that the hydrogel retained its integrity and efficacy over an extended period under various storage conditions. In conclusion, the Herbo-cool hydrogel sheet represents a promising natural intervention against HSV, effectively combining traditional herbal medicine with modern hydrogel technology.

Keywords: Garlic, Oatmeal, Cucumber, Hydrogel, Herpes Simplex Virus, Anti-Viral, Anti-inflammatory, Wound healing.