Abstract

IN SILICO DEMONSTRATION OF ANTI-AGING WITH THE USE OF RESVERATROL ASSOCIATED WITH NITROGEN BASES APPLYING QUANTUM CHEMISTRY

Yahir Emmanuel Saldaña-Rodríguez, Alexis Yael Lopez-Cortes, Adrián MundoÁlvarez, Diana Laura Pino-Dircio, Edith González-Castillo, Olivia Alejandra Garcia-Paz, Verónica Hernández-Fernández PhD and Manuel González-Pérez*

Abstract

Resveratrol (RVT) is a well-known polyphenolic compound in several plants, including grape seeds, peanuts, and other food sources such as wine. RVT is quite famous for its association with various health benefits such as anti-obesity, neuro-protective cardioprotective, antitumor, anti-diabetic, antioxidant, anti-aging effects, and glucose metabolism. Hyperchem software was used as a quantum chemistry simulator. The fundamental basis of quantum calculations was the Electron Transfer Coefficient (ETC) theory. As a result of these calculations, it is observed that the RVT is located at the bottom of the well. This location leads us to infer that RVT is a long-acting substance; due to this location, the biological organism cannot quickly eliminate this substance. Another finding shows us that this molecule presents a quantum superposition of HOMO and LUMO. This quantum property infers that the RVT forms spheres or micelles naturally. RVT is an excellent antioxidant for nitrogenous bases (BN).

Keywords: Resveratrol, Anti-aging, Quantum Chemistry, Nitrogen Bases, Antiinflammatory.