Abstract

ANALYSIS OF IVERMECTIN AND THE RELATIONSHIP WITH NEUROTRANSMITTERS USING QUANTUM CHEMISTRY

Alexis Yael Lopez-Cortes, Yahir Emmanuel Saldaña-Rodriguez, Adrián Mundo-Alvarez, Diana Laura Pino-Dircio, Olivia Alejandra García-Paz, Edith González-Castillo, Verónica Hernández-Fernández PhD and Manuel Gonzalez-Pérez*

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Abstract

Ivermectin (IVM) is currently the most successful drug in the avermectin family and was approved by the FDA for use in humans. Hyperchem software was used as a quantum chemistry simulator. The theory of the electron transfer coefficient (ETC) was the fundamental basis of quantum calculations. As a result, the ETC is lower when the IVM acts as an oxidant. This result confirms the role of IVM as an excellent oxidant of adrenaline. This finding opens intriguing possibilities for future research and possible applications in pharmacology and neurochemistry and sparks curiosity about the possible implications of this interaction. On the other hand, and with other neurotransmitters, it is concluded that IVM is a better oxidant than antioxidant of several neurotransmitters.

Keywords: Ivermectin, GABA, Quantum Chemistry, Glycine, Anthelmintics.