Abstract

REVIEW ON TASTE MASKING

Anuja A. Malgunde*, Sayali S. Thorbole and Apeksha V. Masal

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Abstract

Taste is an important parameter in case of drugs administering orally and is a critical factor to be considered while formulating or dispersible, melt in mouth, buccal tablet and other formulations which comes in contact with taste buds. Bitter and unpalatable taste is a major problem of certain drugs in formulations. Masking the bitter taste of drugs is a potential tool for the improvement of patient compliance which in turn decides the Taste refers to a perception arising from the stimulation of taste buds present on the surface of the tongue. Human‟s commercial success of the product. According to the year 2003 survey of paediatricians by the American Association of Paediatrics, unpleasant taste was the biggest barrier for completing treatment in paediatrics. The field of taste masking of active pharmaceutical ingredients (API) has been continuously evolving with varied technologies and new excipients. Two approaches are commonly utilized to overcome the bad taste of the drug. The first includes reduction of drug solubility in the saliva and second approach is to alter the ability of the drug to interact with taste receptor. Various methods are available to mask the undesirable taste of the drugs. Some of them are coating of drug particles, by formation of inclusion complexes, molecular complexes of drugs with other chemicals, solid dispersions, melting method, micro encapsulation, prodrugs, mass extrusion methods and ion exchange resins.

Keywords: Taste, taste masking, formulations of taste masking.