Abstract

HYDROGEL FOR WOUND HEALING IN DIABETIC FOOT ULCER

Vishwakarma Kuldeep Nandlal*, Amit Bind, Shivanshu, Saurabh Gupta and Anurag Modanwal

Abstract

Diabetes-related foot ulcers are a common and significant global health concern. Hydrogel dressings are among the many types of dressings available to clinicians and patients, and they are an essential component of ulcer care. If left untreated, diabetic foot ulcers (DFU), a common and frequently incapacitating consequence of diabetes, can lead to lower limb amputations. Hydrogel dressings are made of threedimensional networks of hydrophilic polymers, which have been demonstrated to have good fluid management, minimal toxicity, and excellent biocompatibility. They can absorb and retain considerable volumes of water. Moreover, hydrogels facilitate angiogenesis, migration, and proliferation of cells by generating a moist wound environment that aids in wound healing. We will go over the many ways that DFU hydrogels are prepared in detail and also go over the different kinds of hydrogels that are used in DFU research. We also summarize the most important discoveries, point out open issues, and provide a projection for this fascinating field's future growth. Diabetes-related wounds typically have high rates of amputation, recurrence, and mortality. As a result, managing these wounds has become an international responsibility. Diabetes wound care has been greatly aided by wound dressings, which have undergone constant innovation to acquire numerous remarkable qualities. With their significant moisture retention, biocompatibility, and therapeutic qualities, hydrogel dressings have emerged as one of the most appealing and promising types of wound dressings.

Keywords: Diabetic Foot Ulcer (DFU), Hydrogel wound Dressings, Skin Tissue Engineering, Angiogenesis, Tissue Adhesive, Etc.